Cholylglycine (CG) is a crystalline bile acid involved in the emulsification of fats. It occurs as a sodium salt in the bile of mammals. It is a conjugate of cholic acid with glycine. Its anion is called glycocholate.Cholyglycine (CG) has clinical usefulness and the determinations of serum CG gave additional information of various liver diseases ^[1]. Of the biliary acids rountinely measured by radioimmunoassay, CG was found to be the most sensitive in liver diseases ^[2].Raised CG serum levels are associated with liver dysfunction. Measurement of fasting CG levels could be useful as a marker of severity in the evaluation and follow-up of cirrhotic patients, and could be applied along with other commonly used liver tests. Although there are other sensitive tests such as albumin and prothrombin time in advanced cirrhosis, their sensitivity is notably lower than that of CG determination at earlier disease stages ^[3].When liver cells are damaged, their capacity for CG reabsorption is reduced resulting in an increase of blood CG concentration, and may be used for detection of a variety hepatobiliary conditions, such as liver cancer, cirrhosis, viral hepatitis, pediatric liver diseases, and alcoholic liver disease ^[4-11].

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 [1] Tanggo Y, Fujiyama S, Kin F, et al. Clinical usefulness of serum cholylglycine determination in various liver diseases[J]. Journal of Gastroenterology, 1982, 17(5):447-452.

[2] Andreuzzi B, Val C, Santese R, Andreuzzi P CAUTONI L: Clinico-diagnostic significance of the determination of bile acids in chronic liver disease [in Italian]. Minverva Med 1984, 75: 749-756.

[3] Julio Collazos, Julio de Miguel and Alvaro Ruibal, Cholyglycine serum levels in cirrhosis: a clinical and laboratory evaluation, European Journal of Gatroenterology & Hepatology 1994, 6: 175-178.

[4] Azer SA, Coverdale SA, Byth K, Farrell GC, Stacey NH. Se-quential changes in serum levels of individual bile acids in patients with chronic cholestatic liver disease. J Gastroenterol Hepatol. 1996 Mar;11(3):208-15.

[5] Changbumrung S, Tungtrongchitr R, Migasena P, Chamroenngan S. Serum unconjugated primary and secondary bile acids in patients with cholangiocarcinoma and hepatocellular carcinoma. J Med Assoc Thai. 1990 Feb;73(2):81-90.

[6] Collazos J. Glycocholic acid in chronic active hepatitis and mild liver diseases. Clin Investig. 1993 Dec;72(1): 36-9.

[7] Collazos J, Mendarte U, De Miguel J. Clinical value of the determination of fasting glycocholic acid serum levels in patients with liver diseases. A comparison with standard liver tests. Gastroenterol Clin Biol. 1993;17(2):79-82.

[8] Lopez JB, Balasegaram M, Thambyrajah V, Timor J. The value of liver function tests in hepatocellular carcinoma. Malays. J Pathol. 1996 Dec;18(2):95-99.